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The development of the rst generation of genetically engineered foods was focused on enhancing the bottom line that is, on providing enhanced yield, pest control, extended shelf life, with little regard for nutrition. For example, the rst commercial bioengineered crop, a tobacco resistant to a plant virus and a cash crop, was developed in China in 1988. Similarly, the rst bioengineered food product endorsed by the United States Food and Drug Administration was a form of chymosin, an enzyme used in the production of cheese. The natural form of chymosin is not only more ex pensive than the bioengineered version, but the supply tends to be erratic. What s more, because it didn t directly appear in cheese, there was no need to differentiate between bioengineered and natural chymosin on the pack age label. The rst engineered true food approved by the FDA for the United States consumer market was the Calgene FlavrSavr Tomato, introduced in the early 1990s. The tomato, created by inserting a gene from a pig into the tomato s genome, had an extended shelf life that meant it wouldn t rot in transit from the farms to the retail stores. Unlike bioengineered chy mosin, the FlavrSavr tomato was an economic disaster when consumers learned that the gene responsible for the FlavrSavr s resilience came from a pig. Despite the failure of the FlavrSavr tomato, by the end of the 1990s, there were over a dozen genetically modi ed crops in the United States de signed for high yield or for resistance to pesticides. In the area of pest control, the interest in creating genetically modi ed plants with built-in pesticides stems in part from the selectivity of the pesticides that can be developed. A major problem with traditional,

(7.2.29) (7.2.30)

1/Jinc(r) + 1/Js(r)

You may want to de ne other properties that expose the object state in different ways For example, it is common for a business object to have a Boolean IsDirty property that identi es whether an entity has been changed Although the EntityStateEnum could be used to determine this, adding an IsDirty property provides a shortcut:

(7.2.31)

1P~1)(r) = L f~- _11Pinc(rl)

(7.2.32a)

1P~1) (r) =

L 1P;(1) (r)

''' <summary> ''' Gets whether the business object has changes ''' </summary> ''' <value>True or False</value> ''' <returns>True if there are unsaved changes; ''' False if not</returns> ''' <remarks></remarks> Protected ReadOnly Property IsDirty() As Boolean Get Return MeEntityState <> EntityStateEnumUnchanged End Get End Property

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broad-spectrum pesticides that are applied externally to crops, such as DDT and Malathion, is that they are associated with cancer and other diseases in humans and vertebrates, and have long-lasting, far-reaching effects on the environment Another motivation for creating crops with built-in resistance to infec tion or insects is economic For example, consider Monsanto s genetically engineered Roundup Ready/YieldGuard corn It produces an insecticidal protein derived from a bacterial gene that makes it fatal to corn borer lar vae, eliminating the need for a farmer to use an insecticide More impor tantly, from Monsanto s perspective, the corn has a built-in tolerance to Monsanto s Roundup herbicide, which means that only Monsanto s weed killer can be applied directly to the corn without stunting the corn s growth In this way, Monsanto effectively eliminates competition for weed killer.

(7.2.32b)

(7.2.32c)

1P;(n+1) (r) = 1Pinc(r)

+ ~ f Ir _ rll1Pf(n) (rl)

This property does not have its own private backing variable Instead, it uses the value of the EntityState property You also need code that manages the state This is normally implemented as a method:

Zel]

(7.2.33)

(7.2.34)

1Pj = 1Pf(rj)

''' <summary> ''' Changes the state of the entity ''' </summary> ''' <param name="dataState">New entity state</param> ''' <remarks></remarks> Protected Sub DataStateChanged(ByVal dataState As EntityStateEnum) ' If the state is deleted, mark it as deleted If dataState = EntityStateEnumDeleted Then MeEntityState = dataState End If ' Only set data states if the existing state is unchanged If MeEntityState = EntityStateEnumUnchanged _ OrElse dataState = EntityStateEnumUnchanged Then MeEntityState = dataState End If End Sub

Even though the genetically modi ed corn locks farmers into one brand of herbicide, within a year of its introduction in 2000, over a million acres of it were planted in the United States The development of plants with enhanced yield and extended shelf life is a boon to many third-world countries, where the ability to produce more crops that last longer often means the difference between life and death for tens of thousands of people every year In Kenya, where the sweet potato is a major staple, crop yields are limited by infection from insect-borne viruses that can t be controlled by agricultural chemicals Bioengineered, virus resistant sweet potatoes were successfully introduced into Kenya in 2001 to combat the virus Similarly, in 1998, Cornell University, the Uni versity of Hawaii, and Monsanto engineered a papaya that is resistant to the papaya ring spot virus.

eik!ri-rj!

(7.2.35) (7.2.36) (7.2.37)

A ij = f 1_ - - I ri rj bj = 1Pinc(rj)

(7.2.38)

(7.2.39)

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